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According to Ukrainian President Volodymyr Zelensky, Ukrainian forces struck targets in six Russian regions and the Black Sea overnight. Two Russian defense plants were targeted in the Tula and Voronezh regions, and oil facilities were hit in the Krasnodar region.

Strikes also hit facilities used for drone attacks in the Kaluga and Oryol regions, and Russian troops were targeted directly in the Bryansk region. An additional target was struck in the Black Sea.

Ukrainian forces struck the Tsymbulovo drone launch site in the Oryol region of Russia on September 21. The facility, which is used to launch attack drones including jet-powered types against Ukraine, sustained reported damage to bunkers and hangars. Several drones were burned at a UAV preparation area, and multiple impacts and detonations were observed.

Preliminary information indicates that UAVs and Neptune missiles were used in the attack.

Overnight, several infrastructure and oil targets in the Russian oblasts of Smolensk, Oryol, Kursk, and Rostov became targets of Ukrainian drone attack. Additionally, the krai of Krasnodar came under attack.

Explosions can be heard in various videos.

The Afip oil refinery in Krasnodar Krai can be seen burning.